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Movies from these publications

Egeblad, M., A. J. Ewald, H. A. Askautrud, B. E. Welm, M. Truitt, E. Bainbridge, G. Peeters, M. Krummell & Z. Werb (2008). Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy. Disease Models Mech. 1:155-167.

Ewald, A.J., A. Brenot, M. Duong, B.S. Chan & Z. Werb (2008). Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis. Dev. Cell. 14:570-581.

Welm, B.E., G.J.P. Dijkgraaf, A.S. Bledau, A.L. Welm & Z. Werb (2008). Lentiviral Transduction of Mammary Stem Cells for Analysis of Gene Function during Development and Cancer. Cell Stem Cell 2008 2: 90-102.

Foxp3+ regulatory T cells migrate along blood vessels and at the tumor-stroma border
CD11c+ dendritic-like cells migrate at the tumor-stroma border
CD11c+ dendritic-like cells migrate at the tumor-stroma border, but not deeper within the tumor mass
c-fms+ myeloid cells migrate in the normal mammary gland
Infiltration and migration of c-fms+ myeloid cells vary with the tumor microenvironment
Migration of Foxp3+ regulatory T-lymphocytes is stopped in response to hypoxia
Dextran-ingesting c-fms+ myeloid cells do not migrate, whereas c-fms+ cells that do not ingest dextran migrate in the same microenvironment
Carcinoma-associated fibroblasts in different tumor microenvironments
Gr1+ myeloid cells are a patrolling subpopulation of tumor-infiltrating myeloid cells
Movie 1. Branching Organoid
Movie 2. Lumen Clearing
Movie 3. Lumen Filling
Movie 4. Ductal Initiation
Movie 5. Ductal Elongation and Bifurcation (3D Reconstruction)
Movie 6. Transition from Multilayered to Single-Layered Epithelium in the Elongating Tips
Movie 7. Cells Dynamically Rearranging within an Elongating Duct
Movie 8. Cells Rearranging within an Elongating Duct as It Transitions from a Multilayer to a Single Layer
Movie 9. Rac-1 Inhibitor Treated Organoid
Movie 10. MLCK Inhibitor Treated Organoid
Movie 11. Control Organoid
Movie 12. ROCK Inhibitor Treated Organoid
Movie 14. ROCK Inhibitor treated Branching Organoid
Movie 15. ROCK Inhibitor Treated Organoid (3D Reconstruction)
Movie 16. ROCK Inhibitor Treated Organoid (3D Reconstruction)
Movie 17. Addition (22 Hr) and Washout (69 Hr of Culture; 45 Hr into the Movie) of ROCK Inhibitor
Alternating Red and Green Fluorescent Channels of Figure 3A of an Outgrowth from Mixed Red and Green Fluorescent MECs Transplanted at Nonlimiting Dilution that Contains Ducts with an Amalgamation of Fluorescent Patterns
Alternating Red and Green Fluorescent Channels of Figure 3B of an Outgrowth from Mixed Red and Green Fluorescent MECs Transplanted at Nonlimiting Dilution that Contains Ducts with an Amalgamation of Fluorescent Patterns
Alternating Red and Green Fluorescent Channels of Figure 3C of an Outgrowth from Mixed Red and Green Fluorescent MECs Transplanted at Nonlimiting Dilution that Contains Ducts with an Amalgamation of Fluorescent Patterns
Alternating Red and Green Fluorescent Channels of Figure 3D of an Outgrowth from Mixed Red and Green Fluorescent MECs Transplanted at Nonlimiting Dilution that Contains Ducts with an Amalgamation of Fluorescent Patterns

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Foxp3+ regulatory T cells migrate along blood vessels and at the tumor-stroma border

CD11c+ dendritic-like cells migrate at the tumor-stroma border

CD11c+ dendritic-like cells migrate at the tumor-stroma border, but not deeper within the tumor mass

c-fms+ myeloid cells migrate in the normal mammary gland

Infiltration and migration of c-fms+ myeloid cells vary with the tumor microenvironment

Migration of Foxp3+ regulatory T-lymphocytes is stopped in response to hypoxia

Dextran-ingesting c-fms+ myeloid cells do not migrate, whereas c-fms+ cells that do not ingest dextran migrate in the same microenvironment

Carcinoma-associated fibroblasts in different tumor microenvironments

Gr1+ myeloid cells are a patrolling subpopulation of tumor-infiltrating myeloid cells

Movie 1. Branching Organoid

Movie 2. Lumen Clearing

Movie 3. Lumen Filling

Movie 4. Ductal Initiation

Movie 5. Ductal Elongation and Bifurcation (3D Reconstruction)

Movie 6. Transition from Multilayered to Single-Layered Epithelium in the Elongating Tips

Movie 7. Cells Dynamically Rearranging within an Elongating Duct

Movie 8. Cells Rearranging within an Elongating Duct as It Transitions from a Multilayer to a Single Layer

Movie 9. Rac-1 Inhibitor Treated Organoid

Movie 10. MLCK Inhibitor Treated Organoid

Movie 11. Control Organoid

Movie 12. ROCK Inhibitor Treated Organoid

Movie 14. ROCK Inhibitor treated Branching Organoid

Movie 15. ROCK Inhibitor Treated Organoid (3D Reconstruction)

Movie 16. ROCK Inhibitor Treated Organoid (3D Reconstruction)

Movie 17. Addition (22 Hr) and Washout (69 Hr of Culture; 45 Hr into the Movie) of ROCK Inhibitor

Alternating Red and Green Fluorescent Channels of Figure 3A of an Outgrowth from Mixed Red and Green Fluorescent MECs Transplanted at Nonlimiting Dilution that Contains Ducts with an Amalgamation of Fluorescent Patterns

Alternating Red and Green Fluorescent Channels of Figure 3B of an Outgrowth from Mixed Red and Green Fluorescent MECs Transplanted at Nonlimiting Dilution that Contains Ducts with an Amalgamation of Fluorescent Patterns

Alternating Red and Green Fluorescent Channels of Figure 3C of an Outgrowth from Mixed Red and Green Fluorescent MECs Transplanted at Nonlimiting Dilution that Contains Ducts with an Amalgamation of Fluorescent Patterns

Alternating Red and Green Fluorescent Channels of Figure 3D of an Outgrowth from Mixed Red and Green Fluorescent MECs Transplanted at Nonlimiting Dilution that Contains Ducts with an Amalgamation of Fluorescent Patterns