Juliane studied Pharmacy at the University of Leipzig and received her Ph.D. at the University of Heidelberg. In her Ph.D. work, she focused on the influence of nuclear transport mechanisms on the development and progression of hepatocellular carcinoma (HCC). Eukaryotic cells fundamentally rely on a selective and highly efficient nucleocytoplasmic transport system. In a cancer cell almost all cellular processes and signaling cascades are dependent on a nuclear transport for maintaining their malignant phenotype. Juliane found, that a special nuclear transport cycle, CAS/importin-α1, is highly deregulated in HCC and required to maintain an aggressive phenotype in vitro and in vivo. In her current postdoc project Juliane is interested in the role of the nucleocytoplasmic transport machinery on metastasis development of breast cancer.
Winkler J, Sticht C, DiGuilio AL, Holzer K, Eiteneuer E, Esther Herpel, Breuhahn K, Gretz N, Roessler S, Schirmacher P, Ori A & Singer S (2016) Cellular Apoptosis Susceptibility (CAS) is linked to integrin β1 and required for tumor cell migration and invasion in hepatocellular carcinoma (HCC) Oncotarget doi:10.18632/oncotarget.8256
Holzer K, Drucker E, Oliver S, Winkler J, Eiteneuer E, Herpel E, Breuhahn K & Singer S (2016) Cellular apoptosis susceptibility (CAS) is overexpressed in thyroid carcinoma and maintains tumor cell growth: A potential link to the BRAFV600E mutation. Int J Oncol 48(4):1679-87. doi: 10.3892/ijo.2016.3388
Macher-Goeppinger S, Keith M, Tagscherer KE, Singer S, Winkler J, Hofmann TG, Pahernik S, Duensing S, Hohenfellner M, Kopitz J, Schirmacher P & Roth W (2015) PBRM1 (BAF180) protein is functionally regulated by p53-induced protein degradation in renal cell carcinomas. The Journal of pathology 237:460–471 doi: 10.1002/path.4592
Winkler J, Ori A, Holzer K, Sticht C, Dauch D, Eiteneuer EM, Pinna F, Geffers R, Ehemann V, Andres-Pons A, Breuhahn K, Longerich T, Bermejo JL, Gretz N, Zender L, Schirmacher P, Beck M & Singer S (2014) Prosurvival function of the cellular apoptosis susceptibility/importin-α1 transport cycle is repressed by p53 in liver cancer. Hepatology (Baltimore, Md.) 60: 884–895 doi: 10.1002/hep.2720