Hugo Gonzalez-Velozo

Lab Profile

Hugo Gonzalez Velozo
Postdoctoral Fellow

Hugo received his PhD from the Universidad Andres Bello of Chile, where he worked with Prof. Rodrigo Pacheco in the associate Institute Fundación Ciencia & Vida. In his PhD, he used a mouse model of Parkinson's Disease to dissect the role of the adaptive immune system during neuroinflammacion and neurodegeneration. In the Werb lab, Hugo is interested in the molecular mechanisms that sustain the infiltration, survival and proliferation of cancer cells in the brain parenchyma during metastatic dissemination from breast cancer.  

Contreras, F., Prado, C., González, H., Franz, D., Osorio-Barrios, F., Osorio, F., Ugalde, V., Lopez, E., Elgueta, D., Figueroa, A., Lladser, A., Pacheco, R. Dopamine receptor D3 signaling on CD4+ T cells favors Th1-and Th17-mediated immunity (2016) Journal of Immunology, 196 (10), pp. 4143-4149.

Moraga-Amaro, R., González, H., Ugalde, V., Donoso-Ramos, J.P., Quintana-Donoso, D., Lara, M., Morales, B., Rojas, P., Pacheco, R., Stehberg, J. Dopamine receptor D5 deficiency results in a selective reduction of hippocampal NMDA receptor subunit NR2B expression and impaired memory (2016) Neuropharmacology, 103, pp. 222-235.

González, H., Contreras, F., Pacheco, R. Regulation of the Neurodegenerative Process Associated to Parkinson’s Disease by CD4+ T-cells (2015) Journal of Neuroimmune Pharmacology, 10 (4), pp. 561-575.

Franz, D., Contreras, F., González, H., Prado, C., Elgueta, D., Figueroa, C., Pacheco, R. Dopamine receptors D3 and D5 regulate CD4<sup>+</sup>T-cell activation and differentiation by modulating ERK activation and cAMP production (2015) Journal of Neuroimmunology, 284, pp. 18-29.

González, H., Pacheco, R. T-cell-mediated regulation of neuroinflammation involved in neurodegenerative diseases (2014) Journal of Neuroinflammation, 11 (1), art. no. 201

Moraga-Amaro, R., Gonzalez, H., Pacheco, R., Stehberg, J. Dopamine receptor D3 deficiency results in chronic depression and anxiety (2014) Behavioural Brain Research, 274, pp. 186-193.

González, H., Elgueta, D., Montoya, A., Pacheco, R. Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases (2014) Journal of Neuroimmunology, 274 (1-2), pp. 1-13.

Fernández-Suárez, D., Celorrio, M., Riezu-Boj, J.I., Ugarte, A., Pacheco, R., González, H., Oyarzabal, J., Hillard, C.J., Franco, R., Aymerich, M.S. The monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model (2014) Neurobiology of Aging, 35 (11), pp. 2603-2616.

González, H., Contreras, F., Prado, C., Elgueta, D., Franz, D., Bernales, S., Pacheco, R. Dopamine receptor D3 expressed on CD4+ T cells favors neurodegeneration of dopaminergic neurons during parkinson's disease (2013) Journal of Immunology, 190 (10), pp. 5048-5056.

Prado, C., Contreras, F., González, H., Díaz, P., Elgueta, D., Barrientos, M., Herrada, A.A., Lladser, A., Bernales, S., Pacheco, R. Stimulation of dopamine receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity (2012) Journal of Immunology, 188 (7), pp. 3062-3070.