MD degree, Lund University
PhD degree, Lund University
Thesis title: The impact of Wnt5a signaling and tumor associated macrophages in breast cancer.
Dr. Hagerling is interested in how immune cells and cancer stem cells modulate the metastatic niche and contribute to metastatic breast cancer. To this end she uses patient-derived xenograft models of human breast cancer and single-cell approaches to identify cancer stem cells and subpopulations of metastasis associated myeloid cells. The overarching aim of her projects is to find novel ways to identify and therapeutically target cancer cells and immune cells, and thereby prevent recurrence and fight metastatic breast cancer.
Catharina Hagerling, Amy-Jo Casbon and Zena Werb, Balancing the innate immune system in tumor development,
Trends Cell Biol. 2014 Nov 28, Review
Catharina Medrek*, Fredrik Pontén, Karin Jirströmand Karin Leandersson, The presence of tumor associated macrophages in tumor stroma as aprognostic marker for breast cancer patients, BMC Cancer. 2012 Jul 23; 12 (1): 306.
Caroline Bergenfelz, Catharina Medrek*, ElinEkström, Karin Jirström, Helena Janols, MarleneWullt, Anders Bredberg, Karin Leandersson, Wnt5a induces a tolerogenic phenotype of macrophages in sepsis and breast cancer patients, J Immunol. 2012Jun 1; 188 (11): 5448-58
Catharina Medrek*, Göran Landberg, TommyAndersson and Karin Leandersson, Wnt-5a-CKIαsignaling promotes β-catenin/E-cadherin complexformation and intercellular adhesion in human breast epithelial cells, J Biol Chem. 2009 Apr 17;284 (16): 10968-79
*Former last name was Medrek.